The effects of lycopene supplementation on serum insulin-like growth factor 1 (IGF-1) levels and cardiovascular disease: A dose-response meta-analysis of clinical trials.
Complement Ther Med
; 56: 102632, 2021 Jan.
Article
en En
| MEDLINE
| ID: mdl-33259908
ABSTRACT
BACKGROUND:
The results of human studies assessing the efficacy of lycopene on insulin-like growth factor 1 (IGF-1) levels are inconsistent. Thus, we performed a systematic review and meta-analysis to examine the effects of lycopene supplementation on serum IGF-1 levels and cardiovascular disease.METHODS:
The literature published up to January 2020 was searched using the electronic databases Scopus, PubMed/Medline, Web of Science, Embase and Google Scholar.RESULTS:
Seven qualified trials were included in the current meta-analysis. IGF-1 levels were non-significantly decreased in lycopene group compared to the control (WMD -6.74 ng/mL, 95 % CI -23.01 to 9.52, p = 0.42; I2 = 94.3 %). Subgroup analysis revealed a significantly decrease in IGF-1 levels upon lycopene supplementation at doses ≥15 mg/d (WMD -6.40 ng/mL), intervention period <12 weeks (WMD -6.49 ng/mL), and subjects aged ≥60 years (WMD -24.98 mg/dl). In addition, lycopene intake significantly reduced IGF-1 levels upon healthy conditions (WMD -25.59 ng/mL) when compared with cancer patients (WMD 0.35 ng/mL). In addition, the effect of lycopene supplementation was significant in patients diagnosed with cardiac disorders.CONCLUSION:
Overall, lycopene intake was not associated with reduced serum IGF-1 levels. However, association was significant when lycopene was administrated at doses >15 mg/d, for <12 weeks, as well as for healthy conditions and patients aged ≥60 years. In addition, lycopene supplementation exhibited potential health benefits in the management of patients with cardiac disorders.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Factor I del Crecimiento Similar a la Insulina
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Enfermedades Cardiovasculares
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Licopeno
Tipo de estudio:
Clinical_trials
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Systematic_reviews
Idioma:
En
Revista:
Complement Ther Med
Año:
2021
Tipo del documento:
Article
País de afiliación:
China