Massiliamide, a cyclic tetrapeptide with potent tyrosinase inhibitory properties from the Gram-negative bacterium Massilia albidiflava DSM 17472T.
J Antibiot (Tokyo)
; 74(4): 269-272, 2021 04.
Article
en En
| MEDLINE
| ID: mdl-33361781
ABSTRACT
A cyclic tetrapeptide, designated massiliamide, was isolated from the liquid culture of the Gram-negative bacterium Massilia albidiflava DSM 17472T. The structure was elucidated through extensive spectroscopic analysis, including HR-MS and 1D and 2D NMR experiments. The absolute configuration was determined using the Marfey´s method. Massiliamide showed potent inhibitory activity towards tyrosinase with an IC50 value of 1.15 µM and no cytotoxicity.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Péptidos Cíclicos
/
Monofenol Monooxigenasa
/
Oxalobacteraceae
/
Inhibidores Enzimáticos
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
2021
Tipo del documento:
Article
País de afiliación:
Alemania