The protective effect of Veronica ciliata Fisch. Extracts on relieving oxidative stress-induced liver injury via activating AMPK/p62/Nrf2 pathway.

Lu, Qiuxia; Shu, Yueyue; Wang, Li; Li, Guoxiu; Zhang, Shiyan; Gu, Wanqin; Sun, Yiran; Hua, Wan; Huang, Lei; Chen, Fang; Tang, Lin

Lu, Qiuxia; Shu, Yueyue; Wang, Li; Li, Guoxiu; Zhang, Shiyan; Gu, Wanqin; Sun, Yiran; Hua, Wan; Huang, Lei; Chen, Fang; Tang, Lin.

Afiliación

Lu Q; Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China; National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application, Chengdu, China; College of Food and Biological Engineering,
Shu Y; Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China; National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application, Chengdu, China.
Wang L; Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China; National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application, Chengdu, China.
Li G; Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China; National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application, Chengdu, China.
Zhang S; Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China; National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application, Chengdu, China.
Gu W; Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China; National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application, Chengdu, China.
Sun Y; Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China; National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application, Chengdu, China.
Hua W; Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China; National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application, Chengdu, China.
Huang L; State Key Laboratory of Functions & Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China.
Chen F; Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China; National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application, Chengdu, China.
Tang L; Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China; National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application, Chengdu, China. Electronic address: tanglin@scu.edu.cn.

J Ethnopharmacol ; 270: 113775, 2021 Apr 24.

Article en En | MEDLINE | ID: mdl-33406386

Asunto(s)

Proteínas Quinasas Activadas por AMP/metabolismo; Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico; Factor 2 Relacionado con NF-E2/metabolismo; Extractos Vegetales/farmacología; Sustancias Protectoras/farmacología; Proteína Sequestosoma-1/metabolismo; Veronica/química; Animales; Apoptosis/efectos de los fármacos; Autofagia/efectos de los fármacos; Línea Celular; Enfermedad Hepática Inducida por Sustancias y Drogas/patología; Etanol/toxicidad; Inflamación/tratamiento farmacológico; Proteína 1 Asociada A ECH Tipo Kelch/metabolismo; Luteolina/farmacología; Masculino; Ratones Endogámicos ICR; Simulación del Acoplamiento Molecular; Factor 2 Relacionado con NF-E2/genética; Estrés Oxidativo/efectos de los fármacos; Extractos Vegetales/química; Extractos Vegetales/uso terapéutico; Sustancias Protectoras/química; Sustancias Protectoras/uso terapéutico; Ratas; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos; terc-Butilhidroperóxido/toxicidad

Palabras clave

AMPK/p62/Nrf2 pathway; Hepatoprotective constitutions; Liver damage; Oxidative stress; Veronica ciliata Fisch.

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Texto completo: 1 Bases de datos: MEDLINE Medicinas Tradicionales: Medicinas_tradicionales_de_asia / Medicina_tibetana Medicinas Complementárias: Homeopatia Asunto principal: Extractos Vegetales / Sustancias Protectoras / Veronica / Factor 2 Relacionado con NF-E2 / Proteínas Quinasas Activadas por AMP / Enfermedad Hepática Inducida por Sustancias y Drogas / Proteína Sequestosoma-1 Tipo de estudio: Prognostic_studies Idioma: En Revista: J Ethnopharmacol Año: 2021 Tipo del documento: Article

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