Withaferin A exerts an anti-obesity effect by increasing energy expenditure through thermogenic gene expression in high-fat diet-fed obese mice.

Lee, Da-Hye; Park, So-Hyun; Lee, Eunyoung; Seo, Hyo-Deok; Ahn, Jiyun; Jang, Young-Jin; Ha, Tae-Youl; Im, Seung Soon; Jung, Chang Hwa

Lee, Da-Hye; Park, So-Hyun; Lee, Eunyoung; Seo, Hyo-Deok; Ahn, Jiyun; Jang, Young-Jin; Ha, Tae-Youl; Im, Seung Soon; Jung, Chang Hwa.

Afiliación

Lee DH; Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Jeonbuk 55365, Republic of Korea; Department of Food Biotechnology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Park SH; Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Jeonbuk 55365, Republic of Korea; Department of Food Biotechnology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Lee E; Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Jeonbuk 55365, Republic of Korea.
Seo HD; Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Jeonbuk 55365, Republic of Korea.
Ahn J; Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Jeonbuk 55365, Republic of Korea; Department of Food Biotechnology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Jang YJ; Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Jeonbuk 55365, Republic of Korea.
Ha TY; Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Jeonbuk 55365, Republic of Korea; Department of Food Biotechnology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Im SS; Department of Physiology, Keimyung University School of Medicine, Daegu, 42601, Republic of Korea.
Jung CH; Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Jeonbuk 55365, Republic of Korea; Department of Food Biotechnology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address: chjung@kfri.re.kr.

Phytomedicine ; 82: 153457, 2021 Feb.

Article en En | MEDLINE | ID: mdl-33444942

Asunto(s)

Fármacos Antiobesidad/farmacología; Dieta Alta en Grasa; Metabolismo Energético/efectos de los fármacos; Expresión Génica/efectos de los fármacos; Obesidad/tratamiento farmacológico; Termogénesis/efectos de los fármacos; Witanólidos/uso terapéutico; Proteínas Quinasas Activadas por AMP/metabolismo; Tejido Adiposo Pardo/efectos de los fármacos; Tejido Adiposo Pardo/metabolismo; Tejido Adiposo Blanco/efectos de los fármacos; Tejido Adiposo Blanco/metabolismo; Animales; Peso Corporal/efectos de los fármacos; Masculino; Ratones; Ratones Endogámicos C57BL; Ratones Obesos; Mitocondrias/metabolismo; Termogénesis/genética; Proteína Desacopladora 1/metabolismo; Withania/química; Witanólidos/farmacología

Palabras clave

AMP-activated protein kinase; Adipose tissue browning; Energy expenditure; Mitochondrial activity; Mitogen-activated protein kinase; Withaferin A

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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Plantas_medicinales Asunto principal: Expresión Génica / Fármacos Antiobesidad / Termogénesis / Metabolismo Energético / Witanólidos / Dieta Alta en Grasa / Obesidad Tipo de estudio: Health_economic_evaluation Idioma: En Revista: Phytomedicine Año: 2021 Tipo del documento: Article

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