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In Vivo-to-In Vitro Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach.
Kumar, Aditya R; Prasad, Bhagwat; Bhatt, Deepak Kumar; Mathialagan, Sumathy; Varma, Manthena V S; Unadkat, Jashvant D.
Afiliación
  • Kumar AR; Department of Pharmaceutics, University of Washington, Seattle, Washington (A.R.K., B.P., D.K.B., J.D.U.); and Pharmacokinetics, Pharmacodynamics, and Metabolism, Medicine Design, Pfizer Inc., Groton, Connecticut (S.M., M.V.S.V.).
  • Prasad B; Department of Pharmaceutics, University of Washington, Seattle, Washington (A.R.K., B.P., D.K.B., J.D.U.); and Pharmacokinetics, Pharmacodynamics, and Metabolism, Medicine Design, Pfizer Inc., Groton, Connecticut (S.M., M.V.S.V.).
  • Bhatt DK; Department of Pharmaceutics, University of Washington, Seattle, Washington (A.R.K., B.P., D.K.B., J.D.U.); and Pharmacokinetics, Pharmacodynamics, and Metabolism, Medicine Design, Pfizer Inc., Groton, Connecticut (S.M., M.V.S.V.).
  • Mathialagan S; Department of Pharmaceutics, University of Washington, Seattle, Washington (A.R.K., B.P., D.K.B., J.D.U.); and Pharmacokinetics, Pharmacodynamics, and Metabolism, Medicine Design, Pfizer Inc., Groton, Connecticut (S.M., M.V.S.V.).
  • Varma MVS; Department of Pharmaceutics, University of Washington, Seattle, Washington (A.R.K., B.P., D.K.B., J.D.U.); and Pharmacokinetics, Pharmacodynamics, and Metabolism, Medicine Design, Pfizer Inc., Groton, Connecticut (S.M., M.V.S.V.).
  • Unadkat JD; Department of Pharmaceutics, University of Washington, Seattle, Washington (A.R.K., B.P., D.K.B., J.D.U.); and Pharmacokinetics, Pharmacodynamics, and Metabolism, Medicine Design, Pfizer Inc., Groton, Connecticut (S.M., M.V.S.V.) jash@u.washington.edu.
Drug Metab Dispos ; 49(6): 470-478, 2020 06.
Article en En | MEDLINE | ID: mdl-33824168
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transportadores de Anión Orgánico / Interacciones Farmacológicas / Eliminación Renal / Vías de Eliminación de Fármacos Tipo de estudio: Prognostic_studies Idioma: En Revista: Drug Metab Dispos Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transportadores de Anión Orgánico / Interacciones Farmacológicas / Eliminación Renal / Vías de Eliminación de Fármacos Tipo de estudio: Prognostic_studies Idioma: En Revista: Drug Metab Dispos Año: 2020 Tipo del documento: Article