Diphenhydramine and levofloxacin combination therapy against antimicrobial resistance in respiratory tract infections.
Future Microbiol
; 16: 409-420, 2021 04.
Article
en En
| MEDLINE
| ID: mdl-33847144
ABSTRACT
Background:
Antibiotics are in use since decades to treat various infections caused by Gram-positive and Gram-negative bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa. Diphenhydramine, an H1 receptor blocker possesses a weak antibiotic action but when combined with other antibiotics may potentiate their antibacterial activity. Materials &methods:
This study investigated in vitro antibacterial activity of diphenhydramine when used alone and in combination with levofloxacin against methicillin-resistant S. aureus and P. aeruginosa.Results:
The combined antibacterial effect of the drugs against bacteria showed a fractional inhibitory concentration index of ≤0.5, in other words, synergism. No cytotoxicity was observed as percentage cell viability was >50%.Conclusion:
The combination of diphenhydramine and levofloxacin exerted antibacterial activity, and was not found to be cytotoxic when given in combination against P. aeruginosa and S. aureus.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Plantas_medicinales
Asunto principal:
Infecciones del Sistema Respiratorio
/
Farmacorresistencia Bacteriana
/
Difenhidramina
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Levofloxacino
/
Antibacterianos
Idioma:
En
Revista:
Future Microbiol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Pakistán