Chemical constituents with inhibition against TNF-α from Merrillanthus hainanensis.
Fitoterapia
; 152: 104938, 2021 Jul.
Article
en En
| MEDLINE
| ID: mdl-34022295
ABSTRACT
Two new steroidal glycosides oxystauntoside A (1) and oxystauntoside B (2), together with sixteen known compounds (3-18) were isolated from the 95% ethanol extract of Merrillanthus hainanensis. Their structures were characterized by extensive spectroscopic analysis including NMR and mass spectra and single crystal X-ray crystallography. The absolute configuration of 1 and 2 were further determined by ECD calculations. All of these compounds were isolated from M. hainanensis for the first time. All the fractions and compounds were tested for the anti-inflammatory activity against the TNF-α factor. The ethyl acetate fraction showed the most potent inhibition (71.3%) at 10 µg/mL and compounds 5 (78.9%) and 9 (73.4%) in this fraction with both carboxyl and phenolic hydroxyl groups showed significant inhibition at 10 µM. Our study provided the first scientific report for the medicinal value of M. hainanensis.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Esteroides
/
Factor de Necrosis Tumoral alfa
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Apocynaceae
/
Glicósidos
/
Antiinflamatorios
País/Región como asunto:
Asia
Idioma:
En
Revista:
Fitoterapia
Año:
2021
Tipo del documento:
Article
País de afiliación:
China