Repeated hypoxia exposure induces cognitive dysfunction, brain inflammation, and amyloidß/<i>p</i>-Tau accumulation through reduced brain <i>O</i>-GlcNAcylation in zebrafish.

Park, Jiwon; Jung, Sunhee; Kim, Sang-Min; Park, In Young; Bui, Ngan An; Hwang, Geum-Sook; Han, Inn-Oc

Repeated hypoxia exposure induces cognitive dysfunction, brain inflammation, and amyloidß/p-Tau accumulation through reduced brain O-GlcNAcylation in zebrafish.

Park, Jiwon; Jung, Sunhee; Kim, Sang-Min; Park, In Young; Bui, Ngan An; Hwang, Geum-Sook; Han, Inn-Oc.

Afiliación

Park J; Department of Biomedical Science, Program in Biomedical Science and Engineering, College of Medicine, Inha University, Incheon, Korea.
Jung S; Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute.
Kim SM; Department of Biomedical Science, Program in Biomedical Science and Engineering, College of Medicine, Inha University, Incheon, Korea.
Park IY; Department of Biomedical Science, Program in Biomedical Science and Engineering, College of Medicine, Inha University, Incheon, Korea.
Bui NA; Department of Biomedical Science, Program in Biomedical Science and Engineering, College of Medicine, Inha University, Incheon, Korea.
Hwang GS; Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute.
Han IO; Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea.

J Cereb Blood Flow Metab ; 41(11): 3111-3126, 2021 11.

Article en En | MEDLINE | ID: mdl-34176340

Asunto(s)

Péptidos beta-Amiloides/metabolismo; Disfunción Cognitiva/metabolismo; Glucosamina/farmacología; Hipoxia/metabolismo; Pez Cebra/metabolismo; Proteínas tau/metabolismo; Animales; Ansiedad/metabolismo; Encéfalo/metabolismo; Estudios de Casos y Controles; Disfunción Cognitiva/etiología; Encefalitis/metabolismo; Femenino; Cromatografía de Gases y Espectrometría de Masas/métodos; Glucosamina/metabolismo; Glucosamina/uso terapéutico; Glucosa/metabolismo; Hipoxia/complicaciones; Hipoxia Encefálica/metabolismo; Hipoxia Encefálica/prevención & control; Discapacidades para el Aprendizaje/metabolismo; Masculino; Trastornos de la Memoria/metabolismo; N-Acetilglucosaminiltransferasas/metabolismo; Proteínas de Pez Cebra/metabolismo; beta-N-Acetilhexosaminidasas/metabolismo

Palabras clave

Alzheimer's disease; Danio Rerio; LTM; O-GlcNAcase; hypoxic brain damage

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pez Cebra / Péptidos beta-Amiloides / Proteínas tau / Disfunción Cognitiva / Glucosamina / Hipoxia Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: J Cereb Blood Flow Metab Año: 2021 Tipo del documento: Article

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