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Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection.
Dampalla, Chamandi S; Zheng, Jian; Perera, Krishani Dinali; Wong, Lok-Yin Roy; Meyerholz, David K; Nguyen, Harry Nhat; Kashipathy, Maithri M; Battaile, Kevin P; Lovell, Scott; Kim, Yunjeong; Perlman, Stanley; Groutas, William C; Chang, Kyeong-Ok.
Afiliación
  • Dampalla CS; Department of Chemistry, Wichita State University, Wichita, KS 67260.
  • Zheng J; Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA 52242.
  • Perera KD; Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506.
  • Wong LR; Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA 52242.
  • Meyerholz DK; Department of Pathology, The University of Iowa, Iowa City, IA 52242.
  • Nguyen HN; Department of Chemistry, Wichita State University, Wichita, KS 67260.
  • Kashipathy MM; Protein Structure Laboratory, The University of Kansas, Lawrence, KS 66047.
  • Battaile KP; NYX, New York Structural Biology Center, Upton, NY 11973.
  • Lovell S; Protein Structure Laboratory, The University of Kansas, Lawrence, KS 66047.
  • Kim Y; Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506; ykim@ksu.edu stanley-perlman@uiowa.edu bill.groutas@wichita.edu kchang@vet.ksu.edu.
  • Perlman S; Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA 52242; ykim@ksu.edu stanley-perlman@uiowa.edu bill.groutas@wichita.edu kchang@vet.ksu.edu.
  • Groutas WC; Department of Chemistry, Wichita State University, Wichita, KS 67260; ykim@ksu.edu stanley-perlman@uiowa.edu bill.groutas@wichita.edu kchang@vet.ksu.edu.
  • Chang KO; Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506; ykim@ksu.edu stanley-perlman@uiowa.edu bill.groutas@wichita.edu kchang@vet.ksu.edu.
Proc Natl Acad Sci U S A ; 118(29)2021 07 20.
Article en En | MEDLINE | ID: mdl-34210738
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Inhibidores de Proteasas / Pirrolidinas / Proteasas 3C de Coronavirus / Proteasas Similares a la Papaína de Coronavirus / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Inhibidores de Proteasas / Pirrolidinas / Proteasas 3C de Coronavirus / Proteasas Similares a la Papaína de Coronavirus / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article