Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-ß1/Smad2, NF-&#954;B, and AMPK signaling pathways.

Liu, Guancheng; Cui, Zhe; Gao, Xiaoyan; Liu, Huizhe; Wang, Linghe; Gong, Jinyan; Wang, Ao; Zhang, Jianxiu; Ma, Qianqian; Huang, Yuan; Piao, Guangchun; Yuan, Haidan

Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-ß1/Smad2, NF-κB, and AMPK signaling pathways.

Liu, Guancheng; Cui, Zhe; Gao, Xiaoyan; Liu, Huizhe; Wang, Linghe; Gong, Jinyan; Wang, Ao; Zhang, Jianxiu; Ma, Qianqian; Huang, Yuan; Piao, Guangchun; Yuan, Haidan.

Afiliación

Liu G; College of Pharmacy, Yanbian University, Jilin, China.
Cui Z; Department of Pharmacy, Yanbian University Hospital, Jilin, China.
Gao X; College of Pharmacy, Yanbian University, Jilin, China.
Liu H; College of Pharmacy, Yanbian University, Jilin, China.
Wang L; College of Integration Science, Yanbian University, Jilin, China.
Gong J; College of Pharmacy, Yanbian University, Jilin, China.
Wang A; College of Pharmacy, Yanbian University, Jilin, China.
Zhang J; College of Pharmacy, Yanbian University, Jilin, China.
Ma Q; College of Pharmacy, Yanbian University, Jilin, China.
Huang Y; Department of Gastroenterology, Yanbian University Hospital, Jilin, China.
Piao G; College of Pharmacy, Yanbian University, Jilin, China.
Yuan H; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Jilin, China.

Phytother Res ; 35(9): 5214-5226, 2021 Sep.

Article en En | MEDLINE | ID: mdl-34213784

Asunto(s)

Enfermedad del Hígado Graso no Alcohólico; Transducción de Señal/efectos de los fármacos; Triterpenos; Proteínas Quinasas Activadas por AMP/metabolismo; Animales; Tetracloruro de Carbono; Dieta Alta en Grasa/efectos adversos; Hígado/metabolismo; Cirrosis Hepática; Ratones; FN-kappa B/metabolismo; Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico; Proteína Smad2; Factor de Crecimiento Transformador beta1/metabolismo; Triterpenos/farmacología

Palabras clave

AMPK; NF-κB; TGF-ß1/Smad2; corosolic acid; liver fibrosis

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Texto completo: 1 Bases de datos: MEDLINE Medicinas Tradicionales: Medicinas_tradicionales_de_asia / Medicina_china Asunto principal: Triterpenos / Transducción de Señal / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Prognostic_studies Idioma: En Revista: Phytother Res Año: 2021 Tipo del documento: Article País de afiliación: China

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