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Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis.
Wang, Shujin; Schianchi, Francesco; Neumann, Dietbert; Wong, Li-Yen; Sun, Aomin; van Nieuwenhoven, Frans A; Zeegers, Maurice P; Strzelecka, Agnieszka; Col, Umare; Glatz, Jan F C; Nabben, Miranda; Luiken, Joost J F P.
Afiliación
  • Wang S; Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands; Institute of Life Sciences, Chongqing Medical University, Chongqing, PR China.
  • Schianchi F; Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
  • Neumann D; Department of Pathology, Maastricht University Medical Center+, Maastricht, the Netherlands; CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands.
  • Wong LY; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, the Netherlands.
  • Sun A; Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
  • van Nieuwenhoven FA; Department of Physiology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands; CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands.
  • Zeegers MP; Department of Complex Genetics and Epidemiology, School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands.
  • Strzelecka A; Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
  • Col U; Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
  • Glatz JFC; Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, the Netherlands.
  • Nabben M; Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, the Netherlands; CARIM School for Cardiovascular Diseases, Maastricht, the
  • Luiken JJFP; Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, the Netherlands. Electronic address: j.luiken@maastrichtuniversity.nl.
Mol Metab ; 53: 101293, 2021 11.
Article en En | MEDLINE | ID: mdl-34265467
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ATPasas de Translocación de Protón Vacuolares / Miocitos Cardíacos / Serina-Treonina Quinasas TOR / Aminoácidos Idioma: En Revista: Mol Metab Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ATPasas de Translocación de Protón Vacuolares / Miocitos Cardíacos / Serina-Treonina Quinasas TOR / Aminoácidos Idioma: En Revista: Mol Metab Año: 2021 Tipo del documento: Article