Benzoylcyclopropane Derivatives from Hypoxis hemerocallidea Corms.
Planta Med
; 88(8): 685-692, 2022 Jul.
Article
en En
| MEDLINE
| ID: mdl-34331304
ABSTRACT
Two monobenzoylcyclopropane (hypoxhemerol A (1 ) and hypoxhemeroloside G (2 )) and three dibenzoylcyclopropane (hypoxhemerol B (3 ), hypoxhemeroloside H (4 ), and hypoxhemeroloside I (5 )) derivatives were isolated from the hydro-alcoholic extract of Hypoxis hemerocallidea corms. This is the first instance where benzoylcyclopropane analogs were isolated from any natural source. Structure elucidation was mainly based on 1D- and 2D-NMR and HRESIMS data. The absolute configuration (2R, 4R) of 1 was determined via NOESY NMR and experimental and calculated ECD data analyses. Compounds 1 -5 and 11 recently reported metabolites (hypoxoside, obtuside A, interjectin, acuminoside, curcapicycloside, and hypoxhemerolosides Aâ-âF) were screened for in vitro antimicrobial activity against various bacterial and fungal strains. Curcapicycloside and acuminoside exhibited antibacterial activity against Escherichia coli with 78 and 79% inhibition at 20 µg/mL, respectively. Hypoxhemeroloside A showed mild antifungal activity against Cryptococcus neoformans with 63% inhibition at 20 µg/mL.
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1
Bases de datos:
MEDLINE
Asunto principal:
Hypoxis
Idioma:
En
Revista:
Planta Med
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos