Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of <i>Leishmania donovani</i>.

Hassan, Ahmed H E; Phan, Trong-Nhat; Yoon, Seolmin; Lee, Cheol Jung; Jeon, Hye Rim; Kim, Seung-Hwan; No, Joo Hwan; Lee, Yong Sup

Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani.

Hassan, Ahmed H E; Phan, Trong-Nhat; Yoon, Seolmin; Lee, Cheol Jung; Jeon, Hye Rim; Kim, Seung-Hwan; No, Joo Hwan; Lee, Yong Sup.

Afiliación

Hassan AHE; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Phan TN; Medicinal Chemistry Laboratory, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
Yoon S; Leishmania Research Laboratory, Institut Pasteur Korea, Seongnam-si, Korea.
Lee CJ; Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
Jeon HR; Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
Kim SH; Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
No JH; Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
Lee YS; Leishmania Research Laboratory, Institut Pasteur Korea, Seongnam-si, Korea.

J Enzyme Inhib Med Chem ; 36(1): 1922-1930, 2021 Dec.

Article en En | MEDLINE | ID: mdl-34425714

Asunto(s)

Antiprotozoarios/química; Leishmania donovani/efectos de los fármacos; Fosforilcolina/química; Pirrolidinas/química; Amida Sintasas/metabolismo; Antiprotozoarios/farmacología; Evaluación Preclínica de Medicamentos; Humanos; Conformación Molecular; Simulación del Acoplamiento Molecular; Palmitatos/química; Pirrolidinas/farmacología; Esfingomielinas/química; Relación Estructura-Actividad

Palabras clave

Antileishmanial agents; IPCS; amastigotes; inositol phosphoceramide synthase; molecular docking; promastigotes; repurposing; sphingomyelin

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fosforilcolina / Pirrolidinas / Leishmania donovani / Antiprotozoarios Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: J Enzyme Inhib Med Chem Año: 2021 Tipo del documento: Article País de afiliación: Egipto

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