Your browser doesn't support javascript.
loading
Shared and specific patterns of structural and functional thalamo-frontal disturbances in manic and euthymic pediatric bipolar disorder.
Guo, Yi-Bing; Gao, Wei-Jia; Long, Zhi-Liang; Cao, Wei-Fang; Cui, Dong; Guo, Yong-Xin; Jiao, Qing; Qiu, Jian-Feng; Su, Lin-Yan; Lu, Guang-Ming.
Afiliación
  • Guo YB; Faculty of Psychology, Southwest University, Chongqing, 400715, China.
  • Gao WJ; Research School of Psychology, The Australian National University, Canberra, Australia.
  • Long ZL; Department of Child Psychology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, Zhejiang, China.
  • Cao WF; Faculty of Psychology, Southwest University, Chongqing, 400715, China.
  • Cui D; Department of Radiology, Shandong First Medical University &Shandong Academy of Medical Sciences, Tai'an, 271016, Shandong Province, China.
  • Guo YX; Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, 300192, China.
  • Jiao Q; Department of Radiology, Shandong First Medical University &Shandong Academy of Medical Sciences, Tai'an, 271016, Shandong Province, China.
  • Qiu JF; Department of Radiology, Shandong First Medical University &Shandong Academy of Medical Sciences, Tai'an, 271016, Shandong Province, China. bingbao17@163.com.
  • Su LY; Department of Radiology, Shandong First Medical University &Shandong Academy of Medical Sciences, Tai'an, 271016, Shandong Province, China.
  • Lu GM; Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Brain Imaging Behav ; 15(5): 2671-2680, 2021 Oct.
Article en En | MEDLINE | ID: mdl-34432228
Bipolar disorder (BD) is clinically defined by alternating depressive and manic episodes with a separated period of euthymia. Thalamo-frontal loop plays vital role in psychotic symptoms, altered motor control and executive difficulties in BD. It remains unclear that structural and functional alterations of thalamo-frontal loop among the different mood states in BD, especially in pediatric BD(PBD).Twenty manic PBD (mPBD), 20 euthymic PBD (ePBD) and 19 healthy controls (HCs) were included in the study. By analyzing the T1 images and fMRI signals, thalamus volume and frontal grey matter cortical thickness were tested, and functional connectivity (FC) between bilateral thalamus and frontal cortex was calculated. Relationship between clinical indices and thalamo-frontal FC was also evaluated in mPBD and ePBD adolescents.Compared to HCs, the cortical thickness of left middle frontal gyrus (MFG), bilateral superior frontal gyrus (SFG) was significantly decreased in both mPBD and ePBD patients, and volume of left thalamus and cortical thickness of right MFG significantly decreased in mPBD patients. Compared to that of the HCs and ePBD subjects, thalamo-frontal hyperconnectivity with MFG was found in mPBD, and compared with that of HCs, thalamo-frontal hypoconnectivity with precentral gyrus/SFG was found in ePBD. In ePBD patients, episode times positively correlated with FC values between thalamus and precentral gyrus.The findings of the present study demonstrate detailed knowledge regarding shared and specific structural and functional disruption in thalamo-frontal loop in mPBD and ePBD subjects. Thalamo-frontal abnormalities reported in adult BD subjects were also observed in adolescent BD patients, and thalamo-frontal dysfunction may be a crucial treatment target in BD.
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Trastorno Bipolar Idioma: En Revista: Brain Imaging Behav Año: 2021 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Trastorno Bipolar Idioma: En Revista: Brain Imaging Behav Año: 2021 Tipo del documento: Article País de afiliación: China