Potential Anti-Alzheimer Agents from Guanidinyl Tryptophan Derivatives with Activities of Membrane Adhesion and Conformational Transition Inhibitions.

Wongrattanakamon, Pathomwat; Jiaranaikulwanitch, Jutamas; Vajragupta, Opa; Jiranusornkul, Supat; Saenjum, Chalermpong; Yooin, Wipawadee

Wongrattanakamon, Pathomwat; Jiaranaikulwanitch, Jutamas; Vajragupta, Opa; Jiranusornkul, Supat; Saenjum, Chalermpong; Yooin, Wipawadee.

Afiliación

Wongrattanakamon P; Laboratory for Molecular Design and Simulation (LMDS), Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Jiaranaikulwanitch J; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Vajragupta O; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Jiranusornkul S; Cluster of Excellence on Biodiversity-Based Economic and Society (B.BES-CMU), Chiang Mai University, Chiang Mai 50200, Thailand.
Saenjum C; Office of Research Affairs, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Yooin W; Laboratory for Molecular Design and Simulation (LMDS), Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

Molecules ; 26(16)2021 Aug 11.

Article en En | MEDLINE | ID: mdl-34443456

Asunto(s)

Enfermedad de Alzheimer/tratamiento farmacológico; Péptidos beta-Amiloides/química; Membrana Celular/metabolismo; Guanidina/uso terapéutico; Triptófano/uso terapéutico; Adhesividad; Adsorción; Guanidina/química; Humanos; Ligandos; Membrana Dobles de Lípidos/química; Lípidos/química; Modelos Moleculares; Simulación de Dinámica Molecular; Fosfatidilcolinas/química; Conformación Proteica; Estructura Secundaria de Proteína; Triptófano/química; Agua/química

Palabras clave

Alzheimer's disease; Aß monomer; TGN4; guanidinyl tryptophan compounds; lipid bilayer; molecular dynamics simulation

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Hidroterapia Asunto principal: Triptófano / Membrana Celular / Péptidos beta-Amiloides / Guanidina / Enfermedad de Alzheimer Idioma: En Revista: Molecules Año: 2021 Tipo del documento: Article País de afiliación: Tailandia

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google