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Species selection for nonclinical safety assessment of drug candidates: Examples of current industry practice.
Namdari, Rostam; Jones, Keith; Chuang, Samuel S; Van Cruchten, Steven; Dincer, Zuhal; Downes, Noel; Mikkelsen, Lars Friis; Harding, Joanna; Jäckel, Sven; Jacobsen, Björn; Kinyamu-Akunda, Jacqueline; Lortie, Andréanne; Mhedhbi, Sofiene; Mohr, Susanne; Schmitt, Michael W; Prior, Helen.
Afiliación
  • Namdari R; Xenon Pharmaceuticals Inc, Burnaby, Canada.
  • Jones K; CFMD Ltd, Peterborough, UK. Electronic address: kjones.cfmd@btinternet.com.
  • Chuang SS; Charles River Laboratories, Wilmington, MA, USA.
  • Van Cruchten S; University of Antwerp, Wilrijk, Belgium.
  • Dincer Z; Labcorp Early Development Laboratories Ltd, Harrogate, UK.
  • Downes N; Sequani Ltd, Ledbury, UK.
  • Mikkelsen LF; Ellegaard Göttingen Minipigs, Dalmose, Denmark.
  • Harding J; R&D, AstraZeneca, Cambridge, UK.
  • Jäckel S; Merck KGaA, Darmstadt, Germany.
  • Jacobsen B; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Switzerland.
  • Kinyamu-Akunda J; Janssen Research & Development, Spring House, PA, USA.
  • Lortie A; Ipsen, Les Ulis, France.
  • Mhedhbi S; Bracco Suisse SA, Plan-les-Ouates, Switzerland.
  • Mohr S; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Switzerland.
  • Schmitt MW; Merck KGaA, Darmstadt, Germany.
  • Prior H; National Centre for the Replacement Refinement & Reduction of Animals in Research (NC3Rs), London, UK.
Regul Toxicol Pharmacol ; 126: 105029, 2021 Nov.
Article en En | MEDLINE | ID: mdl-34455009
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pruebas de Toxicidad / Modelos Animales / Industria Farmacéutica / Evaluación Preclínica de Medicamentos Tipo de estudio: Guideline / Prognostic_studies / Qualitative_research / Risk_factors_studies Idioma: En Revista: Regul Toxicol Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Canadá
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pruebas de Toxicidad / Modelos Animales / Industria Farmacéutica / Evaluación Preclínica de Medicamentos Tipo de estudio: Guideline / Prognostic_studies / Qualitative_research / Risk_factors_studies Idioma: En Revista: Regul Toxicol Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Canadá