Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel.

Chulkov, Evgeny G; Smith, Emery; Rohr, Claudia M; Yahya, Nawal A; Park, Sang-Kyu; Scampavia, Louis; Spicer, Timothy P; Marchant, Jonathan S

Chulkov, Evgeny G; Smith, Emery; Rohr, Claudia M; Yahya, Nawal A; Park, Sang-Kyu; Scampavia, Louis; Spicer, Timothy P; Marchant, Jonathan S.

Afiliación

Chulkov EG; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Smith E; Department of Molecular Medicine, Scripps Research, Jupiter, Florida, United States of America.
Rohr CM; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Yahya NA; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Park SK; Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America.
Scampavia L; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Spicer TP; Department of Molecular Medicine, Scripps Research, Jupiter, Florida, United States of America.
Marchant JS; Department of Molecular Medicine, Scripps Research, Jupiter, Florida, United States of America.

PLoS Negl Trop Dis ; 15(11): e0009898, 2021 11.

Article en En | MEDLINE | ID: mdl-34731172

Asunto(s)

Antihelmínticos/farmacología; Proteínas del Helminto/antagonistas & inhibidores; Praziquantel/farmacología; Schistosoma mansoni/metabolismo; Esquistosomiasis mansoni/parasitología; Canales de Potencial de Receptor Transitorio/antagonistas & inhibidores; Animales; Antihelmínticos/química; Calcio/metabolismo; Evaluación Preclínica de Medicamentos; Femenino; Proteínas del Helminto/genética; Proteínas del Helminto/metabolismo; Humanos; Masculino; Ratones; Praziquantel/química; Schistosoma mansoni/efectos de los fármacos; Schistosoma mansoni/genética; Esquistosomiasis mansoni/tratamiento farmacológico; Esquistosomiasis mansoni/metabolismo; Canales de Potencial de Receptor Transitorio/genética; Canales de Potencial de Receptor Transitorio/metabolismo

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Praziquantel / Schistosoma mansoni / Esquistosomiasis mansoni / Proteínas del Helminto / Canales de Potencial de Receptor Transitorio / Antihelmínticos Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: PLoS Negl Trop Dis Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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