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A reactive center loop-based prediction platform to enhance the design of therapeutic SERPINs.
Sanrattana, Wariya; Sefiane, Thibaud; Smits, Simone; van Kleef, Nadine D; Fens, Marcel H; Lenting, Peter J; Maas, Coen; de Maat, Steven.
Afiliación
  • Sanrattana W; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht 3584, The Netherlands.
  • Sefiane T; Laboratory for Haemostasis, Inflammation and Thrombosis, INSERM, Unité Mixte de Recherche 1176, Université Paris-Saclay 94276 Le Kremlin-Bicêtre, France.
  • Smits S; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht 3584, The Netherlands.
  • van Kleef ND; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht 3584, The Netherlands.
  • Fens MH; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584, The Netherlands.
  • Lenting PJ; Laboratory for Haemostasis, Inflammation and Thrombosis, INSERM, Unité Mixte de Recherche 1176, Université Paris-Saclay 94276 Le Kremlin-Bicêtre, France.
  • Maas C; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht 3584, The Netherlands.
  • de Maat S; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht 3584, The Netherlands; s.demaat@umcutrecht.nl.
Proc Natl Acad Sci U S A ; 118(45)2021 11 09.
Article en En | MEDLINE | ID: mdl-34740972

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Diseño de Fármacos / Ingeniería de Proteínas / Modelos Moleculares / Alfa 1-Antitripsina / Inhibidor de Proteína C Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Diseño de Fármacos / Ingeniería de Proteínas / Modelos Moleculares / Alfa 1-Antitripsina / Inhibidor de Proteína C Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos