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Integrative Analysis of the Inflammatory Bowel Disease Serum Metabolome Improves Our Understanding of Genetic Etiology and Points to Novel Putative Therapeutic Targets.
Di'Narzo, Antonio F; Houten, Sander M; Kosoy, Roman; Huang, Ruiqi; Vaz, Frédéric M; Hou, Ruixue; Wei, Gabrielle; Wang, Wenhui; Comella, Phillip H; Dodatko, Tetyana; Rogatsky, Eduard; Stojmirovic, Aleksandar; Brodmerkel, Carrie; Perrigoue, Jacqueline; Hart, Amy; Curran, Mark; Friedman, Joshua R; Zhu, Jun; Agrawal, Manasi; Cho, Judy; Ungaro, Ryan; Dubinsky, Marla C; Sands, Bruce E; Suárez-Fariñas, Mayte; Schadt, Eric E; Colombel, Jean-Frédéric; Kasarskis, Andrew; Hao, Ke; Argmann, Carmen.
Afiliación
  • Di'Narzo AF; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Sema4, Stamford, Connecticut.
  • Houten SM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Icahn Institute for Data Science and Genomic Technology, New York, New York.
  • Kosoy R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Icahn Institute for Data Science and Genomic Technology, New York, New York.
  • Huang R; Center for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Vaz FM; Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Hou R; Center for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Wei G; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Icahn Institute for Data Science and Genomic Technology, New York, New York.
  • Wang W; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Icahn Institute for Data Science and Genomic Technology, New York, New York.
  • Comella PH; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Icahn Institute for Data Science and Genomic Technology, New York, New York.
  • Dodatko T; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Icahn Institute for Data Science and Genomic Technology, New York, New York.
  • Rogatsky E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Icahn Institute for Data Science and Genomic Technology, New York, New York.
  • Stojmirovic A; Janssen R&D, LLC, Spring House, Pennsylvania.
  • Brodmerkel C; Janssen R&D, LLC, Spring House, Pennsylvania.
  • Perrigoue J; Janssen R&D, LLC, Spring House, Pennsylvania.
  • Hart A; Janssen R&D, LLC, Spring House, Pennsylvania.
  • Curran M; Janssen R&D, LLC, Spring House, Pennsylvania.
  • Friedman JR; Janssen R&D, LLC, Spring House, Pennsylvania.
  • Zhu J; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Sema4, Stamford, Connecticut; Icahn Institute for Data Science and Genomic Technology, New York, New York.
  • Agrawal M; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Cho J; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Ungaro R; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Dubinsky MC; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Sands BE; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Suárez-Fariñas M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Schadt EE; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Sema4, Stamford, Connecticut; Icahn Institute for Data Science and Genomic Technology, New York, New York.
  • Colombel JF; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Kasarskis A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Sema4, Stamford, Connecticut; Icahn Institute for Data Science and Genomic Technology, New York, New York; Department of Population Health Science and Policy, Icahn School of Medicine at Mount S
  • Hao K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Sema4, Stamford, Connecticut; Icahn Institute for Data Science and Genomic Technology, New York, New York.
  • Argmann C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Icahn Institute for Data Science and Genomic Technology, New York, New York. Electronic address: carmen.argmann@mssm.edu.
Gastroenterology ; 162(3): 828-843.e11, 2022 03.
Article en En | MEDLINE | ID: mdl-34780722
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Enfermedad de Crohn / Acil-CoA Deshidrogenasa Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Gastroenterology Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Enfermedad de Crohn / Acil-CoA Deshidrogenasa Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Gastroenterology Año: 2022 Tipo del documento: Article