Common bacterial metabolite indole directly activates nociceptive neuron through transient receptor potential ankyrin 1 channel.

Chung, Sena; Kim, Hayun; Kim, Doyun; Lee, Jung Moo; Lee, C Justin; Oh, Seog Bae

Chung, Sena; Kim, Hayun; Kim, Doyun; Lee, Jung Moo; Lee, C Justin; Oh, Seog Bae.

Afiliación

Chung S; Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.
Kim H; Interdisciplinary Program in Neuroscience, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.
Kim D; Department of Neurobiology and Physiology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Lee JM; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea.
Lee CJ; Center for Cognition and Sociality, Institute for Basic Science, Daejeon, Republic of Korea.
Oh SB; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea.

Pain ; 163(8): 1530-1541, 2022 08 01.

Article en En | MEDLINE | ID: mdl-34817438

Asunto(s)

Indoles; Nociceptores; Canal Catiónico TRPA1; Animales; Escherichia coli/metabolismo; Ganglios Espinales; Indoles/farmacología; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Nociceptores/metabolismo; Dolor/inducido químicamente; Dolor/metabolismo; Células Receptoras Sensoriales/metabolismo; Canal Catiónico TRPA1/antagonistas & inhibidores; Canal Catiónico TRPA1/genética

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Nociceptores / Canal Catiónico TRPA1 / Indoles Idioma: En Revista: Pain Año: 2022 Tipo del documento: Article