Curcumin by activation of adenosine A2A receptor stimulates protein kinase a and potentiates inhibitory effect of cangrelor on platelets.
Biochem Biophys Res Commun
; 586: 20-26, 2022 01 01.
Article
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| MEDLINE
| ID: mdl-34823218
ABSTRACT
Curcumin is a natural polyphenol derived from the turmeric plant (Curcuma longa) which exhibits numerous beneficial effects on different cell types. Inhibition of platelet activation by curcumin is well known, however molecular mechanisms of its action on platelets are not fully defined. In this study, we used laser diffraction method for analysis of platelet aggregation and Western blot for analysis of intracellular signaling mechanisms of curcumin effects on platelets. We identified two new molecular mechanisms involved in the inhibitory effects of curcumin on platelet activation. Firstly, curcumin by activation of adenosine A2A receptor stimulated protein kinase A activation and phosphorylation of Vasodilator-stimulated phosphoprotein. Secondly, we demonstrated that curcumin even at low doses, which did not inhibit platelet aggregation, potentiated inhibitory effect of ADP receptor P2Y12 antagonist cangrelor which partly could be explained by activation of adenosine A2A receptor.
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Bases de datos:
MEDLINE
Asunto principal:
Fosfoproteínas
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Plaquetas
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Moléculas de Adhesión Celular
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Activación Plaquetaria
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Adenosina Monofosfato
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Proteínas Quinasas Dependientes de AMP Cíclico
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Curcumina
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Receptor de Adenosina A2A
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Proteínas de Microfilamentos
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2022
Tipo del documento:
Article