Iron toxicity in intracerebral hemorrhage: Physiopathological and therapeutic implications.
Brain Res Bull
; 178: 144-154, 2022 01.
Article
en En
| MEDLINE
| ID: mdl-34838852
ABSTRACT
Intracerebral hemorrhage (ICH)-induced brain injury is a continuous pathological process that involves the deterioration of neurological functions, such as sensory, cognitive or motor functions. Cytotoxic byproducts of red blood cell lysis, especially free iron, appear to be a significant pathophysiologic mechanism leading to ICH-induced injury. Free iron has a crucial role in secondary brain injury after ICH. Chelating iron may attenuate iron-induced neurotoxicity and may be developed as a therapeutic candidate for ICH treatment. In this review, we focused on the potential role of iron toxicity in ICH-induced injury and iron chelation therapy in the management of ICH. It will hopefully advance our understanding of the pathogenesis of ICH and lead to new approaches for treatment.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Hemorragia Cerebral
/
Quelantes del Hierro
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Síndromes de Neurotoxicidad
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Ferroptosis
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Hierro
Idioma:
En
Revista:
Brain Res Bull
Año:
2022
Tipo del documento:
Article
País de afiliación:
China