Silibinin relieves UVB-induced apoptosis of human skin cells by inhibiting the YAP-p73 pathway.

Liu, Wei-Wei; Wang, Fang; Li, Can; Song, Xiao-Yu; Otkur, Wuxiyar; Zhu, Yu-Ying; Hayashi, Toshihiko; Mizuno, Kazunori; Hattori, Shunji; Fujisaki, Hitomi; Ikejima, Takashi

Liu, Wei-Wei; Wang, Fang; Li, Can; Song, Xiao-Yu; Otkur, Wuxiyar; Zhu, Yu-Ying; Hayashi, Toshihiko; Mizuno, Kazunori; Hattori, Shunji; Fujisaki, Hitomi; Ikejima, Takashi.

Afiliación

Liu WW; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Wang F; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Li C; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Song XY; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Otkur W; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Zhu YY; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
Hayashi T; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Mizuno K; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Hattori S; Department of Chemistry and Life science, School of Advanced Engineering, Kogakuin University, 2665-1, Nakanomachi, Hachioji, Tokyo, 192-0015, Japan.
Fujisaki H; Nippi Research Institute of Biomatrix, Toride, Ibaraki, 302-0017, Japan.
Ikejima T; Nippi Research Institute of Biomatrix, Toride, Ibaraki, 302-0017, Japan.

Acta Pharmacol Sin ; 43(8): 2156-2167, 2022 Aug.

Article en En | MEDLINE | ID: mdl-34912007

Asunto(s)

Silimarina; Apoptosis; Humanos; Recién Nacido; Simulación del Acoplamiento Molecular; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/farmacología; Silibina/farmacología; Silimarina/farmacología

Palabras clave

HFF primary fibroblasts; HaCaT cells; TEAD; UVB; YAP; apoptosis; p73; silibinin; verteporfin

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Texto completo: 1 Asunto principal: Silimarina Idioma: En Revista: Acta Pharmacol Sin Año: 2022 Tipo del documento: Article País de afiliación: China