Delafloxacin for the treatment of adult patients with community-acquired bacterial pneumonia.
Expert Rev Anti Infect Ther
; 20(5): 649-656, 2022 05.
Article
en En
| MEDLINE
| ID: mdl-34913817
ABSTRACT
INTRODUCTION:
Delafloxacin is a novel fluoroquinolone with peculiar characteristics such as a weak acid character, frequent in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA), and a low potential for resistance selection compared with other fluoroquinolones. AREAS COVERED The present narrative review summarizes the available data on the use of delafloxacin for the treatment of community-acquired bacterial pneumonia (CABP). EXPERT OPINION Delafloxacin is a novel fluoroquinolone with a unique profile and some interesting characteristics for the treatment of CABP, such as its marked activity against gram-positive bacteria, including MRSA, the possible use as monotherapy (owing to anti-Gram-negative and anti-atypical bacteria activity), the retained activity against many Gram-positive organisms resistant to other fluoroquinolones, and the availability of both oral and intravenous formulations. The results of the DEFINE-CABP phase-3 randomized controlled trial have shown noninferiority of delafloxacin vs. moxifloxacin for the treatment of CABP, thereby providing a further option for this indication. Against this background, future post-marketing experiences remain of crucial importance for further refining the place in therapy of delafloxacin in the real-life management algorithms of CABP, either as first-line option or step-down/outpatient treatment.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Plantas_medicinales
Asunto principal:
Infecciones Comunitarias Adquiridas
/
Neumonía Bacteriana
/
Staphylococcus aureus Resistente a Meticilina
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
Expert Rev Anti Infect Ther
Año:
2022
Tipo del documento:
Article
País de afiliación:
Italia