Can Photothermal Post-Operative Cancer Treatment Be Induced by a Thermal Trigger?
ACS Appl Mater Interfaces
; 13(51): 60837-60851, 2021 Dec 29.
Article
en En
| MEDLINE
| ID: mdl-34915699
ABSTRACT
One of the current challenges in the post-operative treatment of breast cancer is to develop a local therapeutic vector for preventing recurrence and metastasis. Herein, we develop a core-shell fibrous scaffold comprising phase-change materials and photothermal/chemotherapy agents, as a thermal trigger for programmable-response drug release and synergistic treatment. The scaffold is obtained by in situ growth of a zeolitic imidazolate framework-8 (ZIF-8) shell on the surface of poly(butylene succinate)/lauric acid (PBS/LA) phase-change fibers (PCFs) to create PCF@ZIF-8. After optimizing the core-shell and phase transition behavior, gold nanorods (GNRs) and doxorubicin hydrochloride (DOX) co-loaded PCF@ZIF-8 scaffolds were shown to significantly enhance in vitro and in vivo anticancer efficacy. In a healthy tissue microenvironment at pH 7.4, the ZIF-8 shell ensures the sustained release of DOX. If the tumor recurs, the acidic microenvironment induces the decomposition of the ZIF-8 shell. Under the second near-infrared (NIR-II) laser treatment, GNR-induced thermal not only directly destroys the relapsed tumor cells but also accelerates DOX release by inducing the phase transition of LA. Our study sheds light on a well-designed programmable-response trigger, which provides a promising strategy for post-operative recurrence prevention of cancer.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fototerapia
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Polímeros
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Butileno Glicoles
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Doxorrubicina
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Antibióticos Antineoplásicos
Idioma:
En
Revista:
ACS Appl Mater Interfaces
Año:
2021
Tipo del documento:
Article
País de afiliación:
China