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21,24-Cyclolanostanes revisited: Structural revision and biological evaluation.
Wang, Chao; Wang, Lirong; Wang, Jilong; Li, Yu-Peng; Zhang, Jun-Sheng; Shan, Peipei; Zhang, Hua.
Afiliación
  • Wang C; School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
  • Wang L; Institute of Translational Medicine, the Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266021, China.
  • Wang J; Qingdao Central Hospital, Qingdao 266042, China.
  • Li YP; School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
  • Zhang JS; School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
  • Shan P; Institute of Translational Medicine, the Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266021, China. Electronic address: peipeishan@qdu.edu.cn.
  • Zhang H; School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: bio_zhangh@ujn.edu.cn.
Fitoterapia ; 156: 105101, 2022 Jan.
Article en En | MEDLINE | ID: mdl-34921925
Chemical fractionation of the EtOH extract of a medicinal macro fungus, Inonotus obliquus, afforded an array of lanostane-type triterpenoids (1-11) including two new ones (1 and 8). The structures of these compounds were determined on the basis of spectroscopic analyses, single crystal X-ray crystallography of 3-6 and biosynthetic considerations. With the confirmatory structural information provided by X-ray diffraction analysis in hand, several previously reported 21,24-cyclolanostanes, such as inonotsutriols A-C and (20R,21S,24S)-21,24-cyclopenta-3ß,21,25-trihydroxylanosta-8-ene, were structurally corrected. In addition, the NMR data of other types of 21,24-cyclo triterpenoids were also re-examined and structural revisions were thus suggested. Compounds 2, 6 and 8 showed significant cytostatic effects against a panel of tumor cell lines with IC50 values ranging from 7.80 to 18.5 µM. Further assays established that compound 2 exerted promising in vitro anti-breast cancer potential by inhibiting the proliferation and migration of 4T1 cells.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Triterpenos / Inonotus Idioma: En Revista: Fitoterapia Año: 2022 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Triterpenos / Inonotus Idioma: En Revista: Fitoterapia Año: 2022 Tipo del documento: Article País de afiliación: China