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Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients.
Acebrón-García-de-Eulate, Marta; Mayol-Llinàs, Joan; Holland, Matthew T O; Kim, So Yeon; Brown, Karen P; Marchetti, Chiara; Hess, Jeannine; Di Pietro, Ornella; Mendes, Vitor; Abell, Chris; Floto, R Andres; Coyne, Anthony G; Blundell, Tom L.
Afiliación
  • Acebrón-García-de-Eulate M; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, U.K.
  • Mayol-Llinàs J; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
  • Holland MTO; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
  • Kim SY; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, U.K.
  • Brown KP; Molecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology, University of Cambridge, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K.
  • Marchetti C; Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, CB23 3RE, UK.
  • Hess J; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
  • Di Pietro O; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
  • Mendes V; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
  • Abell C; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, U.K.
  • Floto RA; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
  • Coyne AG; Molecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology, University of Cambridge, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K.
  • Blundell TL; Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, CB23 3RE, UK.
J Med Chem ; 65(3): 2149-2173, 2022 02 10.
Article en En | MEDLINE | ID: mdl-35080396
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oxidorreductasas / Pseudomonas aeruginosa / Proteínas Bacterianas / Antibacterianos Idioma: En Revista: J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oxidorreductasas / Pseudomonas aeruginosa / Proteínas Bacterianas / Antibacterianos Idioma: En Revista: J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido