Correlation among maternal risk factors, gene methylation and disease severity in females with autism spectrum disorder.
Epigenomics
; 14(4): 175-185, 2022 02.
Article
en En
| MEDLINE
| ID: mdl-35081728
Early-life maternal factors can leave marks on the DNA of the developing fetus, including changes in DNA methylation that regulate gene expression levels. These marks can pose an increased risk for several diseases, such as autism spectrum disorder (ASD) and other developmental disorders. In the present study, we searched for links between early-life maternal factors and the methylation levels of ASD-related genes in blood DNA samples of young ASD diagnosed females. We found that high maternal gestational weight gain resulted in increased methylation levels of the BDNF gene, one of the most important genes for brain development. Moreover, lack of maternal folic acid supplementation and low RELN methylation levels resulted in higher disease severity in ASD females.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Trastorno del Espectro Autista
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Epigenomics
Año:
2022
Tipo del documento:
Article
País de afiliación:
Italia