Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia.

Fu, Chen; Wu, Yifan; Liu, Shaojiao; Luo, Chaoqin; Lu, Yuqiao; Liu, Menghan; Wang, Lingfeng; Zhang, Yunling; Liu, Xuemei

Fu, Chen; Wu, Yifan; Liu, Shaojiao; Luo, Chaoqin; Lu, Yuqiao; Liu, Menghan; Wang, Lingfeng; Zhang, Yunling; Liu, Xuemei.

Afiliación

Fu C; Central Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, China. Electronic address: fuchen2003@163.com.
Wu Y; Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: wuyifan2020bucm@126.com.
Liu S; Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: shaojiaoliu2020@163.com.
Luo C; Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: lcq15372315839@126.com.
Lu Y; Office of Academic Research, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, China. Electronic address: yuqiao9132@163.com.
Liu M; Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: menghanliu_tutu@163.com.
Wang L; Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: wanglingfeng6869@163.com.
Zhang Y; Central Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, China; Department of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address: yunlingzhang2004@126.com.
Liu X; Central Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, China. Electronic address: liuxuemeitcm@163.com.

J Ethnopharmacol ; 289: 115021, 2022 May 10.

Article en En | MEDLINE | ID: mdl-35091012

Asunto(s)

Isquemia Encefálica; Disfunción Cognitiva; Medicamentos Herbarios Chinos; Fármacos Neuroprotectores; Rehmannia; Animales; Humanos; Masculino; Ratas; Isquemia Encefálica/tratamiento farmacológico; Estudios de Casos y Controles; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Disfunción Cognitiva/tratamiento farmacológico; Ferroptosis/efectos de los fármacos; Infarto de la Arteria Cerebral Media; Fármacos Neuroprotectores/aislamiento & purificación; Fármacos Neuroprotectores/farmacología; Factor 2 Relacionado con NF-E2/metabolismo; Fosfatidilinositol 3-Quinasa/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Ratas Sprague-Dawley; Rehmannia/química; Transducción de Señal/efectos de los fármacos; Medicamentos Herbarios Chinos/aislamiento & purificación; Medicamentos Herbarios Chinos/farmacología

Palabras clave

Cerebral ischemia; Cognitive impairment; Ferroptosis; Oxidative stress; PI3K/AKT/Nrf2; Rehmannioside A; SLC7A11/GPX4

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Medicinas Tradicionales: Medicinas_tradicionales_de_asia / Medicina_china Asunto principal: Medicamentos Herbarios Chinos / Isquemia Encefálica / Fármacos Neuroprotectores / Rehmannia / Disfunción Cognitiva Tipo de estudio: Observational_studies / Prognostic_studies Idioma: En Revista: J Ethnopharmacol Año: 2022 Tipo del documento: Article

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google