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Secondary metabolites from Detarium microcarpum Guill. and Perr. (Fabaceae).
Fouatio Feudjou, William; Mbock, Arnaud Michel; Tedjon Sielinou, Valerie; Fouotsa, Hugue; Njonté Wouamba, Steven Collins; Kamkumo Gounoue, Racéline; Freeze, Marcel; Stammler, Hans-Georg; Kezeutas Bankeu, Jean Jules; Pierre, Mkounga; Ndjakou Lenta, Bruno; Tiabou Tchinda, Alembert; Sewald, Norbert; Nkengfack, Augustin Ephrem.
Afiliación
  • Fouatio Feudjou W; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon.
  • Mbock AM; Laboratory of Phytochemistry, Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, P.O. Box 13033, Yaoundé, Cameroon.
  • Tedjon Sielinou V; Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon.
  • Fouotsa H; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon.
  • Njonté Wouamba SC; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon.
  • Kamkumo Gounoue R; Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47 Yaoundé, Cameroon.
  • Freeze M; Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon.
  • Stammler HG; Department of Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany.
  • Kezeutas Bankeu JJ; Department of Inorganic and Structural Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany.
  • Pierre M; Department of Chemistry, Faculty of Science, The University of Bamenda, P.O. Box 39, Bambili, Cameroon.
  • Ndjakou Lenta B; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon.
  • Tiabou Tchinda A; Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47 Yaoundé, Cameroon.
  • Sewald N; Laboratory of Phytochemistry, Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, P.O. Box 13033, Yaoundé, Cameroon.
  • Nkengfack AE; Department of Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany.
Z Naturforsch C J Biosci ; 77(5-6): 253-261, 2022 May 25.
Article en En | MEDLINE | ID: mdl-35212491
ABSTRACT
The chemical investigation of the ethanol/water (73) extract of the roots of Detarium microcarpum (Fabaceae) led to the isolation of one new labdane diterpenoid, microcarpin (1) and one new ceramide derivative, microcarpamide (2), along with eight known secondary metabolites (3-10) including, 5-(carboxymethyl)-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid (3), microcarposide (4), rhinocerotinoic acid (5), 1,7-dihydroxy-6-methylxanthone (6), ursolic acid (7), 3ß,23-dihydroxylup-20(29)-en-28-oic acid (8), alphitolic acid (9), and stigmasterol glucoside (10). The structures of these compounds were elucidated based on their spectroscopic data. Although compounds 3 and 4 are known, their crystalline structures are reported here for the first time. These compounds were evaluated in vitro for their antisalmonella activity. The results obtained showed that, microcarpamide (2), microcarposide (4), and rhinocerotinoic acid (5) were moderately active against three salmonella strains Salmonella typhi, Salmonella enteritidis and Salmonella typhimirium, with minimum inhibition concentration values of 76.7 and 153.5 µM.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fabaceae Idioma: En Revista: Z Naturforsch C J Biosci Año: 2022 Tipo del documento: Article País de afiliación: Camerún
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fabaceae Idioma: En Revista: Z Naturforsch C J Biosci Año: 2022 Tipo del documento: Article País de afiliación: Camerún