&#945;-Hederin inhibits the platelet activating factor-induced metastasis of HCC cells through disruption of PAF/PTAFR axis cascaded STAT3/MMP-2 expression.

Cao, Linna; Zhang, Yiwei; Mi, Jinxia; Shi, Zhanhao; Fang, Zhaoqin; Jia, Dongwei; Pan, Zhiqiang; Peng, Peike

α-Hederin inhibits the platelet activating factor-induced metastasis of HCC cells through disruption of PAF/PTAFR axis cascaded STAT3/MMP-2 expression.

Cao, Linna; Zhang, Yiwei; Mi, Jinxia; Shi, Zhanhao; Fang, Zhaoqin; Jia, Dongwei; Pan, Zhiqiang; Peng, Peike.

Afiliación

Cao L; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhang Y; Department of Anesthesiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Mi J; Science and Technology Center, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shi Z; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Fang Z; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jia D; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: jiadongwei@fudan.edu.cn.
Pan Z; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: pzq527@163.com.
Peng P; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: pengpeike@shutcm.edu.cn.

Pharmacol Res ; 178: 106180, 2022 04.

Article en En | MEDLINE | ID: mdl-35288308

Asunto(s)

Carcinoma Hepatocelular; Neoplasias Hepáticas; Metaloproteinasa 2 de la Matriz; Ácido Oleanólico; Factor de Activación Plaquetaria; Saponinas; Carcinoma Hepatocelular/tratamiento farmacológico; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patología; Línea Celular Tumoral; Proteínas de Unión al ADN/metabolismo; Humanos; Neoplasias Hepáticas/tratamiento farmacológico; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patología; Metaloproteinasa 2 de la Matriz/metabolismo; Simulación del Acoplamiento Molecular; Metástasis de la Neoplasia; Ácido Oleanólico/farmacología; Factor de Activación Plaquetaria/antagonistas & inhibidores; Factor de Activación Plaquetaria/metabolismo; Glicoproteínas de Membrana Plaquetaria/metabolismo; Receptores Acoplados a Proteínas G/metabolismo; Factor de Transcripción STAT3; Saponinas/farmacología; Transducción de Señal/efectos de los fármacos

Palabras clave

Cancer metastasis; Hepatocellular carcinoma; Platelet-activating factor; α-Hederin

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ácido Oleanólico / Saponinas / Factor de Activación Plaquetaria / Carcinoma Hepatocelular / Metaloproteinasa 2 de la Matriz / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Idioma: En Revista: Pharmacol Res Año: 2022 Tipo del documento: Article País de afiliación: China

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google