Ginsenoside Rh2 attenuates CDAHFD-induced liver fibrosis in mice by improving intestinal microbial composition and regulating LPS-mediated autophagy.

Chen, Siyu; He, Ziwei; Xie, Wei; Chen, Xuan; Lin, Zhuofeng; Ma, Jisheng; Liu, Zhi; Yang, Shihai; Wang, Yanfang

Chen, Siyu; He, Ziwei; Xie, Wei; Chen, Xuan; Lin, Zhuofeng; Ma, Jisheng; Liu, Zhi; Yang, Shihai; Wang, Yanfang.

Afiliación

Chen S; College of Chinese Medicinal Materials, JiLin Agricultural University, Changchun,130118, China.
He Z; College of Chinese Medicinal Materials, JiLin Agricultural University, Changchun,130118, China.
Xie W; School of Pharmaceutical Sciences, WenZhou Medical University, Wenzhou 325035, China.
Chen X; College of Chinese Medicinal Materials, JiLin Agricultural University, Changchun,130118, China.
Lin Z; School of Pharmaceutical Sciences, WenZhou Medical University, Wenzhou 325035, China.
Ma J; School of Pharmaceutical Sciences, WenZhou Medical University, Wenzhou 325035, China.
Liu Z; College of Chinese Medicinal Materials, JiLin Agricultural University, Changchun,130118, China.
Yang S; College of Chinese Medicinal Materials, JiLin Agricultural University, Changchun,130118, China; Laboratory for cultivation and breeding of medicinal plants of National Administrition of Traditional Chinese Medicine, JiLin Agricultural University, Changchun,130118, China. Electronic address: yangshih
Wang Y; College of Chinese Medicinal Materials, JiLin Agricultural University, Changchun,130118, China; Laboratory for cultivation and breeding of medicinal plants of National Administrition of Traditional Chinese Medicine, JiLin Agricultural University, Changchun,130118, China. Electronic address: yfwang20

Phytomedicine ; 101: 154121, 2022 Jul.

Article en En | MEDLINE | ID: mdl-35489327

Asunto(s)

Lipopolisacáridos; Proteínas Proto-Oncogénicas c-akt; Animales; Autofagia; Ginsenósidos; Células Estrelladas Hepáticas/metabolismo; Humanos; Lipopolisacáridos/farmacología; Hígado/metabolismo; Cirrosis Hepática/metabolismo; Ratones; Proteínas Proto-Oncogénicas c-akt/metabolismo; Serina-Treonina Quinasas TOR/metabolismo

Palabras clave

Autophagy; Ginsenoside Rh2; Hepatic stellate cells; Intestinal microflora; Lipopolysaccharide; Liver fibrosis

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Lipopolisacáridos / Proteínas Proto-Oncogénicas c-akt Idioma: En Revista: Phytomedicine Año: 2022 Tipo del documento: Article País de afiliación: China

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