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Superparamagnetic and highly bioactive SPIONS/bioactive glass nanocomposite and its potential application in magnetic hyperthermia.
Borges, Roger; Ferreira, Letície M; Rettori, Carlos; Lourenço, Isabella M; Seabra, Amedea B; Müller, Frank A; Ferraz, Emanuela Prado; Marques, Marcia M; Miola, Marta; Baino, Francesco; Mamani, Javier B; Gamarra, Lionel F; Marchi, Juliana.
Afiliación
  • Borges R; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados, 5001, Santo André, SP 09210-580, Brazil.
  • Ferreira LM; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados, 5001, Santo André, SP 09210-580, Brazil.
  • Rettori C; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados, 5001, Santo André, SP 09210-580, Brazil; Instituto de Física Gleb Wataghin, Universidade Estadual de Campinas, Rua Sérgio Buarque de Holanda, 777 - Cidade Universitária, Campinas, SP 13083-859, Brazil.
  • Lourenço IM; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados, 5001, Santo André, SP 09210-580, Brazil.
  • Seabra AB; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados, 5001, Santo André, SP 09210-580, Brazil.
  • Müller FA; Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Löbdergraben 32, 07743 Jena, Germany.
  • Ferraz EP; Departamento de Dentística, Faculdade de Odontologia, Universidade de São Paulo, Av. Prof. Lineu Prestes, 2227, Cidade Universitária, São Paulo, SP 05508-000, Brazil.
  • Marques MM; Departamento de Dentística, Faculdade de Odontologia, Universidade de São Paulo, Av. Prof. Lineu Prestes, 2227, Cidade Universitária, São Paulo, SP 05508-000, Brazil; Faculdade de Odontologia, Universidade Ibirapuera, Av. Interlagos, 1329, Chácara Flora, São Paulo, SP 04661-100, Brazil.
  • Miola M; Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi, 24, Turin 10129, Italy.
  • Baino F; Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi, 24, Turin 10129, Italy.
  • Mamani JB; Hospital Israelita Albert Einstein, Av. Albert Einstein, 665, São Paulo, SP 05652-000, Brazil.
  • Gamarra LF; Hospital Israelita Albert Einstein, Av. Albert Einstein, 665, São Paulo, SP 05652-000, Brazil.
  • Marchi J; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados, 5001, Santo André, SP 09210-580, Brazil. Electronic address: juliana.marchi@ufabc.edu.br.
Mater Sci Eng C Mater Biol Appl ; 135: 112655, 2022 Apr.
Article en En | MEDLINE | ID: mdl-35577690
Magnetic bioactive glass-ceramics are biomaterials applied for magnetic hyperthermia in bone cancer treatment, thereby treating the bone tumor besides regenerating the damaged bone. However, combining high bioactivity and high saturation magnetization remains a challenge since the thermal treatment step employed to grow magnetic phases is also related to loss of bioactivity. Here, we propose a new nanocomposite made of superparamagnetic iron oxide nanoparticles (SPIONs) dispersed in a sol-gel-derived bioactive glass matrix, which does not need any thermal treatment for crystallization of magnetic phases. The scanning and transmission electron microscopies, X-ray diffraction, and dynamic light scattering results confirm that the SPIONs are actually embedded in a nanosized glass matrix, thus forming a nanocomposite. Magnetic and calorimetric characterizations evidence their proper behavior for hyperthermia applications, besides evidencing inter-magnetic nanoparticle interactions within the nanocomposite. Bioactivity and in vitro characterizations show that such nanocomposites exhibit apatite-forming properties similar to the highly bioactive parent glass, besides being osteoinductive. This methodology is a new alternative to produce magnetic bioactive materials to which the magnetic properties only rely on the quality of the SPIONs used in the synthesis. Thereby, these nanocomposites can be recognized as a new class of bioactive materials for applications in bone cancer treatment by hyperthermia.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Nanocompuestos / Hipertermia Inducida Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2022 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Nanocompuestos / Hipertermia Inducida Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2022 Tipo del documento: Article País de afiliación: Brasil