Effect of omega-3 fatty acid supplementation on telomere length and telomerase activity: A systematic review of clinical trials.
Prostaglandins Leukot Essent Fatty Acids
; 181: 102451, 2022 06.
Article
en En
| MEDLINE
| ID: mdl-35661999
ABSTRACT
Evidence suggests antioxidant and anti-inflammatory properties of omega-3 polyunsaturated fatty acids (n-3 PUFA). However, the effect of supplementation of this fatty acid profile on the telomere length and the telomerase enzyme activity was not revised yet. The PubMed and Embase® databases were used to search for clinical trials. A total of six clinical trials were revised. Omega-3 PUFA supplementation did not statistically affect telomere length in three out of three studies but affected telomerase activity in two out of four studies. The supplementation increased telomerase enzyme activity in subjects with first-episode schizophrenia. Besides, it decreased telomerase enzyme activity without modulating the effects of Pro12Ala polymorphism on the PPARγ gene in type 2 diabetes subjects. The methodological differences between the studies and the limited number of studies on the theme suggest that further studies are needed to elucidate the effects of n-3 PUFA supplementation on telomere length and telomerase enzyme activity in humans.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ácidos Grasos Omega-3
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Telomerasa
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Diabetes Mellitus Tipo 2
Tipo de estudio:
Prognostic_studies
/
Systematic_reviews
Idioma:
En
Revista:
Prostaglandins Leukot Essent Fatty Acids
Año:
2022
Tipo del documento:
Article