An Integrated Strategy to Identify and Quantify the Quality Markers of Xinkeshu Tablets Based on Spectrum-Effect Relationship, Network Pharmacology, Plasma Pharmacochemistry, and Pharmacodynamics of Zebrafish.

Wei, Yongheng; Nie, Lei; Gao, Lele; Zhong, Liang; Sun, Zhongyu; Yang, Xiangchun; Yue, Jianan; Zeng, Yingzi; Li, Lian; Sun, Jing; Zang, Hengchang

Wei, Yongheng; Nie, Lei; Gao, Lele; Zhong, Liang; Sun, Zhongyu; Yang, Xiangchun; Yue, Jianan; Zeng, Yingzi; Li, Lian; Sun, Jing; Zang, Hengchang.

Afiliación

Wei Y; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Nie L; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Gao L; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Zhong L; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Sun Z; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yang X; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yue J; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Zeng Y; Shandong Wohua Pharmaceutical Technology Co., Ltd., Weifang, China.
Li L; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Sun J; Key Laboratory of Chemical Biology (Ministry of Education), Shandong University, Jinan, China.
Zang H; Qinghai Provincial Key Laboratory of Qinghai-Tibet Plateau Biological Resources, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China.

Front Pharmacol ; 13: 899038, 2022.

Article en En | MEDLINE | ID: mdl-35677447

Palabras clave

Xinkeshu tablets; network pharmacology; pharmacodynamics of zebrafish; plasma pharmacochemistry; quality markers; spectrum-effect relationship

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: China