Self-Assembled Metallacage with Second Near-Infrared Aggregation-Induced Emission for Enhanced Multimodal Theranostics.
J Am Chem Soc
; 144(28): 12825-12833, 2022 07 20.
Article
en En
| MEDLINE
| ID: mdl-35786928
ABSTRACT
The construction of supramolecular coordination complexes (SCCs) featuring prominent cancer theranostic functions is an appealing yet significantly challenging task. In this study, we rationally designed and facilely constructed a prism-like metallacage C-DTTP with efficient fluorescence emission in the second near-infrared (NIR-II) region through the assembly of an aggregation-induced emission-active four-arm ligand with 90° Pt acceptors Pt(PEt3)2(OTf)2. C-DTTP held the longest maximum emission wavelength (1005 nm) compared with those previously reported SCCs up to now and exhibited both a high photothermal conversion efficiency (39.3%) and significantly superior reactive oxygen species generation behavior to the precursor ligand. In vitro and in vivo assessments demonstrated that the metallacage-loaded nanoparticles with excellent biocompatibility and stability were capable of simultaneously affording precise tumor diagnosis and complete tumor elimination by means of NIR-II fluorescence/photothermal dual imaging-guided photodynamic/photothermal synergistic therapy.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fotoquimioterapia
/
Nanopartículas
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Técnicas Fotoacústicas
/
Neoplasias
Idioma:
En
Revista:
J Am Chem Soc
Año:
2022
Tipo del documento:
Article
País de afiliación:
China