Anti-inflammatory flavonoid derivatives from the heartwood of Dalbergia odorifera T. Chen.
Nat Prod Res
; 37(6): 928-935, 2023 Mar.
Article
en En
| MEDLINE
| ID: mdl-35822397
ABSTRACT
Two pairs of flavonoid enantiomers (1a/1b and 2a/2b) together with three known analogues (3-5) were isolated from the heartwood of Dalbergia odorifera T. Chen. Their structures were elucidated by extensive spectroscopic analysis (1 D and 2 D NMR, UV, IR, and HRMS) and experimental and calculated ECD data. Compound 2 features an unusual 2-methyl-3(2H)-furanone moiety forming the C-ring of flavonoid, and its putative biosynthetic pathway is also proposed. Compounds 3â5 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC50 values of 14.7 ± 0.3 µM, 40.2 ± 1.1 µM, and 3.2 ± 0.1 µM, respectively.
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1
Bases de datos:
MEDLINE
Asunto principal:
Flavonoides
/
Dalbergia
Idioma:
En
Revista:
Nat Prod Res
Año:
2023
Tipo del documento:
Article