The Prevention and Reversal of a Phenytoin-Resistant Model by N-acetylcysteine Therapy Involves the Nrf2/P-Glycoprotein Pathway at the Blood-Brain Barrier.

Liu, Qiankun; Wang, You; Tan, Dandan; Liu, Yong; Zhang, Peng; Ma, Limin; Liang, Minxue; Chen, Yangmei

Liu, Qiankun; Wang, You; Tan, Dandan; Liu, Yong; Zhang, Peng; Ma, Limin; Liang, Minxue; Chen, Yangmei.

Afiliación

Liu Q; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.
Wang Y; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.
Tan D; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.
Liu Y; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.
Zhang P; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.
Ma L; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.
Liang M; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.
Chen Y; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China. chenym1997@cqmu.edu.cn.

J Mol Neurosci ; 72(10): 2125-2135, 2022 Oct.

Article en En | MEDLINE | ID: mdl-36028602

Asunto(s)

Epilepsia Refractaria; Fenitoína; Animales; Ratones; Fenitoína/farmacología; Fenitoína/uso terapéutico; Barrera Hematoencefálica/metabolismo; Acetilcisteína/farmacología; Acetilcisteína/uso terapéutico; Acetilcisteína/metabolismo; Nimodipina/farmacología; Anticonvulsivantes/farmacología; Anticonvulsivantes/uso terapéutico; Factor 2 Relacionado con NF-E2/metabolismo; Miembro 1 de la Subfamilia B de Casetes de Unión a ATP/genética; Miembro 1 de la Subfamilia B de Casetes de Unión a ATP/metabolismo; Encéfalo/metabolismo; Epilepsia Refractaria/metabolismo

Palabras clave

Antioxidative stress; Drug-resistant epilepsy; N-acetylcysteine; P-glycoprotein

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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Aromoterapia Asunto principal: Fenitoína / Epilepsia Refractaria Tipo de estudio: Prognostic_studies Idioma: En Revista: J Mol Neurosci Año: 2022 Tipo del documento: Article País de afiliación: China

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