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Ligustilide attenuates airway remodeling in COPD mice by covalently binding to MH2 domain of Smad3 in pulmonary epithelium, disrupting the Smad3-SARA interaction.
Lu, Yu-Jie; Niu, Lin; Shen, Fu-Kui; Yang, Wen; Xie, Yang; Li, Su-Yun; Jiang, Min; Bai, Gang.
Afiliación
  • Lu YJ; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, People's Republic of China.
  • Niu L; Laboratory of Compound Drugs and Systems Biology, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
  • Shen FK; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, People's Republic of China.
  • Yang W; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, People's Republic of China.
  • Xie Y; Department of Respiratory Diseases, The Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, People's Republic of China.
  • Li SY; Department of Respiratory Diseases, The Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, People's Republic of China.
  • Jiang M; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan province & Education Ministry of P.R., China, Henan University of Chinese Medicine, Zhengzhou, People's Republic of China.
  • Bai G; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, People's Republic of China.
Phytother Res ; 37(2): 717-730, 2023 Feb.
Article en En | MEDLINE | ID: mdl-36216328
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad Pulmonar Obstructiva Crónica / Factor de Crecimiento Transformador beta1 Idioma: En Revista: Phytother Res Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad Pulmonar Obstructiva Crónica / Factor de Crecimiento Transformador beta1 Idioma: En Revista: Phytother Res Año: 2023 Tipo del documento: Article