Guggulsterone from Commiphora mukul potentiates anti-glioblastoma efficacy of temozolomide in vitro and in vivo via down-regulating EGFR/PI3K/Akt signaling and NF-&#954;B activation.

Xu, Hong-Bin; Chen, Xian-Zhen; Yu, Zhou-Lun; Xue, Fei

Guggulsterone from Commiphora mukul potentiates anti-glioblastoma efficacy of temozolomide in vitro and in vivo via down-regulating EGFR/PI3K/Akt signaling and NF-κB activation.

Xu, Hong-Bin; Chen, Xian-Zhen; Yu, Zhou-Lun; Xue, Fei.

Afiliación

Xu HB; Department of Pharmacy, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo, 315010, China. Electronic address: jiang_rh@126.com.
Chen XZ; Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China. Electronic address: chenxianzheny@126.com.
Yu ZL; Department of Pharmacy, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210017, China. Electronic address: 765225074@qq.com.
Xue F; Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China. Electronic address: feelingsea@126.com.

J Ethnopharmacol ; 301: 115855, 2023 Jan 30.

Article en En | MEDLINE | ID: mdl-36280019

Asunto(s)

Glioblastoma; FN-kappa B; Ratones; Animales; Humanos; Temozolomida/farmacología; Temozolomida/uso terapéutico; FN-kappa B/metabolismo; Commiphora; Proteínas Proto-Oncogénicas c-akt/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Transducción de Señal; Glioblastoma/tratamiento farmacológico; Apoptosis; Receptores ErbB/metabolismo; Línea Celular Tumoral; Proliferación Celular

Palabras clave

EGFR/PI3K/Akt; Glioblastoma; Guggulsterone; NF-κB; Temozolomide

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: FN-kappa B / Glioblastoma Idioma: En Revista: J Ethnopharmacol Año: 2023 Tipo del documento: Article