Blueberry stem extract and stem active components prevent blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro.
Biosci Biotechnol Biochem
; 87(4): 378-388, 2023 Mar 21.
Article
en En
| MEDLINE
| ID: mdl-36617234
ABSTRACT
Blue light causes retinal damage that can lead to ocular diseases such as age-related macular degeneration. In this study, we determined the protective effect of blueberry stem extract (BStEx) and active components on blue light-emitting diode (LED) light-induced retinal photoreceptor cell damage in vitro. Photoreceptor cells cultured in the presence of BStEx or components were exposed to blue light to induce cell damage. BStEx, fractions of BStEx containing proanthocyanidins, chlorogenic acid, catechin, and epicatechin prevented the cell damage and/or inhibited the generation of reactive oxygen species (ROS). Furthermore, BStEx reduced apoptosis and cell death, and inhibited the phosphorylation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase leading to cellular apoptosis induced by blue light exposure. These findings suggest that BStEx and components exert a protective effect against blue light-induced photoreceptor cell damage through the inhibition of MAPK phosphorylation and ROS production.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Arándanos Azules (Planta)
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Año:
2023
Tipo del documento:
Article
País de afiliación:
Japón