Targeted photothermal release of antibiotics by a graphene nanoribbon-based supramolecular glycomaterial.
Chem Commun (Camb)
; 59(8): 1094-1097, 2023 Jan 24.
Article
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| MEDLINE
| ID: mdl-36625183
ABSTRACT
Here, we report the simple construction of a supramolecular glycomaterial for the targeted delivery of antibiotics to P. aeruginosa in a photothermally-controlled manner. A galactose-pyrene conjugate (Gal-pyr) was developed to self-assemble with graphene nanoribbon-based nanowires via π-π stacking to produce a supramolecular glycomaterial, which exhibits a 1250-fold enhanced binding avidity toward a galactose-selective lectin when compared to Gal-pyr. The as-prepared glycomaterial when loaded with an antibiotic that acts as an inhibitor of the bacterial folic acid biosynthetic pathway eradicated P. aeruginosa-derived biofilms under near-infrared light irradiation due to the strong photothermal effect of the nanowires accelerating antibiotic release.
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MEDLINE
Asunto principal:
Nanotubos de Carbono
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En
Revista:
Chem Commun (Camb)
Año:
2023
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Article