Local drug delivery in the treatment of furcation defects in periodontitis: a systematic review.
Clin Oral Investig
; 27(3): 955-970, 2023 Mar.
Article
en En
| MEDLINE
| ID: mdl-36729235
ABSTRACT
OBJECTIVES:
To evaluate the effect of subgingival administration of various antimicrobials and host-modulating agents in furcation defects as an adjunct to scaling and root planing (SRP) compared to SRP alone or combined with placebo.METHODS:
A systematic review was carried out using MEDLINE-PubMed, Embase, and Scopus for articles up to October 2022 in addition to hand searches. All longitudinal studies that evaluated the effect of subgingival application of antimicrobial and host-modulating agents in furcation defects as adjuncts to SRP compared to SRP alone or SRP + placebo with at least 3 months of follow-up were eligible for inclusion.RESULTS:
A total of eight studies were included. Superior clinical treatment outcomes were shown when alendronate, rosuvastatin, boric acid, simvastatin, and tetracycline (only at 3 months) were utilized in furcation defects in conjunction with SRP alone or SRP + placebo. Significant improvement was reported in radiographic bone defect depth and defect depth reduction when SRP was supplemented with alendronate, rosuvastatin, boric acid, and simvastatin.CONCLUSIONS:
Within the limitations of this review, the adjunctive subgingival administration of medications and host-modulating agents in furcation defects may confer additional clinical and radiographic benefits than non-surgical periodontal treatment alone. Future investigations are needed to confirm their long-term effectiveness. CLINICAL RELEVANCE Local host modulators and antimicrobials may be used supplementary to enhance the clinical and radiographic treatment outcomes of conventional periodontal therapy in furcation defects.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Periodontitis
/
Defectos de Furcación
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Systematic_reviews
Idioma:
En
Revista:
Clin Oral Investig
Año:
2023
Tipo del documento:
Article
País de afiliación:
Grecia