Shouhui Tongbian Capsules induce regression of inflammation to improve intestinal barrier in mice with constipation by targeted binding to Prkaa1: With no obvious toxicity.

Sun, Chenghong; Zhang, Yongkang; Liu, Mingfei; Liu, Zhong; Pan, Lihong; Liang, Hongbao; Liu, Ning; Li, Shirong; Niu, Dejun; Li, Xiangzi; Li, Bin; Cui, Lijuan; Yao, Jingchun; Xiao, Xuefeng; Zhang, Guimin

Sun, Chenghong; Zhang, Yongkang; Liu, Mingfei; Liu, Zhong; Pan, Lihong; Liang, Hongbao; Liu, Ning; Li, Shirong; Niu, Dejun; Li, Xiangzi; Li, Bin; Cui, Lijuan; Yao, Jingchun; Xiao, Xuefeng; Zhang, Guimin.

Afiliación

Sun C; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China.
Zhang Y; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250300, China.
Liu M; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Liu Z; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China; Linyi Key Laboratory for Immunopharmacology and Immunotoxicology of Natural Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 273400, China.
Pan L; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China; Linyi Key Laboratory for Immunopharmacology and Immunotoxicology of Natural Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 273400, China.
Liang H; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China; Linyi Key Laboratory for Immunopharmacology and Immunotoxicology of Natural Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 273400, China.
Liu N; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China.
Li S; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China.
Niu D; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China; Linyi Key Laboratory for Immunopharmacology and Immunotoxicology of Natural Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 273400, China.
Li X; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China; Linyi Key Laboratory for Immunopharmacology and Immunotoxicology of Natural Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 273400, China.
Li B; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China; Linyi Key Laboratory for Immunopharmacology and Immunotoxicology of Natural Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 273400, China.
Cui L; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China; Linyi Key Laboratory for Immunopharmacology and Immunotoxicology of Natural Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 273400, China.
Yao J; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China; Linyi Key Laboratory for Immunopharmacology and Immunotoxicology of Natural Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 273400, China. Electronic
Xiao X; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address: kai1219@163.com.
Zhang G; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, China; Linyi Key Laboratory for Immunopharmacology and Immunotoxicology of Natural Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 273400, China. Electronic

Biomed Pharmacother ; 161: 114495, 2023 May.

Article en En | MEDLINE | ID: mdl-36906969

Asunto(s)

Inflamación; FN-kappa B; Animales; Ratones; Estreñimiento/tratamiento farmacológico; Inflamación/tratamiento farmacológico; Intestinos; FN-kappa B/metabolismo; Transducción de Señal; Proteínas Quinasas Activadas por AMP/metabolismo

Palabras clave

Diosmetin (PubChem CID: 5281612); Emodin (PubChem CID: 3220); Emodin-8-glucoside (PubChem CID: 99649); Feralolide (PubChem CID: 5317333); Hesperetin (PubChem CID: 72281); Intestinal barrier; Intestinal inflammation; Isosakuranin (PubChem CID: 102004611); Luteolin (PubChem CID: 5280445); Prkaa1; Repeated drug administration toxicity test; Shouhui Tongbian Capsules; Staurosporine (PubChem CID: 44259)

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Texto completo: 1 Bases de datos: MEDLINE Medicinas Tradicionales: Medicinas_tradicionales_de_asia / Medicina_china Asunto principal: FN-kappa B / Inflamación Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article País de afiliación: China

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