Advances in receptor chromatography for drug discovery and drug-receptor interaction studies.
Drug Discov Today
; 28(6): 103576, 2023 06.
Article
en En
| MEDLINE
| ID: mdl-37003514
ABSTRACT
Receptor chromatography involves high-throughput separation and accurate drug screening based on specific drug-receptor recognition and affinity, which has been widely used to screen active compounds in complex samples. This review summarizes the immobilization methods for receptors from three aspects random covalent immobilization methods, site-specific covalent immobilization methods and dual-target receptor chromatography. Meanwhile, it focuses on its applications from three angles screening active compounds in natural products, in natural-product-derived DNA-encoded compound libraries and drug-receptor interactions. This review provides new insights for the design and application of receptor chromatography, high-throughput and accurate drug screening, drug-receptor interactions and more.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Productos Biológicos
/
Descubrimiento de Drogas
Idioma:
En
Revista:
Drug Discov Today
Año:
2023
Tipo del documento:
Article
País de afiliación:
China