Phenylbutyric acid robustly increases Npy mRNA expression in hypothalamic neurons by increasing H3K9/14 acetylation at the Npy promoter.

Krunic, Andre; Loganathan, Neruja; Nkechika, Vanessa; Belsham, Denise D

Krunic, Andre; Loganathan, Neruja; Nkechika, Vanessa; Belsham, Denise D.

Afiliación

Krunic A; Department of Physiology, University of Toronto, Toronto, ON, Canada.
Loganathan N; Department of Physiology, University of Toronto, Toronto, ON, Canada.
Nkechika V; Department of Physiology, University of Toronto, Toronto, ON, Canada.
Belsham DD; Department of Physiology, University of Toronto, Toronto, ON, Canada; Department of Medicine, The University of Toronto, ON, Canada; Department of Obstetrics and Gynecology, The University of Toronto, ON, Canada. Electronic address: d.belsham@utoronto.ca.

Biochem Biophys Res Commun ; 658: 18-26, 2023 05 28.

Article en En | MEDLINE | ID: mdl-37011479

Asunto(s)

Histonas; Neuropéptido Y; Neuropéptido Y/genética; Neuropéptido Y/metabolismo; Histonas/metabolismo; Epigénesis Genética; Acetilación; Hipotálamo/metabolismo; Neuronas/metabolismo; Regiones Promotoras Genéticas; ARN Mensajero/genética; ARN Mensajero/metabolismo

Palabras clave

4-Phenylbutyric acid; Epigenetic regulation; Gene regulation; Histone deacetylase inhibitor; Hypothalamus; Neuropeptide Y

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Texto completo: 1 Bases de datos: MEDLINE Medicinas Complementárias: Homeopatia Asunto principal: Neuropéptido Y / Histonas Tipo de estudio: Prognostic_studies Idioma: En Revista: Biochem Biophys Res Commun Año: 2023 Tipo del documento: Article País de afiliación: Canadá

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