Organ-on-a-Chip for Drug Screening: A Bright Future for Sustainability? A Critical Review.
ACS Biomater Sci Eng
; 9(5): 2220-2234, 2023 05 08.
Article
en En
| MEDLINE
| ID: mdl-37014814
ABSTRACT
Globalization has raised concerns about spreading diseases and emphasized the need for quick and efficient methods for drug screening. Established drug efficacy and toxicity approaches have proven obsolete, with a high failure rate in clinical trials. Organ-on-a-chip has emerged as an essential alternative to outdated techniques, precisely simulating important characteristics of organs and predicting drug pharmacokinetics more ethically and efficiently. Although promising, most organ-on-a-chip devices are still manufactured using principles and materials from the micromachining industry. The abusive use of plastic for traditional drug screening methods and device production should be considered when substituting technologies so that the compensation for the generation of plastic waste can be projected. This critical review outlines recent advances for organ-on-a-chip in the industry and estimates the possibility of scaling up its production. Moreover, it analyzes trends in organ-on-a-chip publications and provides suggestions for a more sustainable future for organ-on-a-chip research and production.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Dispositivos Laboratorio en un Chip
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Idioma:
En
Revista:
ACS Biomater Sci Eng
Año:
2023
Tipo del documento:
Article
País de afiliación:
Brasil