A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example.

Hu, En; Li, Zhilin; Li, Teng; Yang, Xueping; Ding, Ruoqi; Jiang, Haoying; Su, Hong; Cheng, Menghan; Yu, Zhe; Li, Haigang; Tang, Tao; Wang, Yang

Hu, En; Li, Zhilin; Li, Teng; Yang, Xueping; Ding, Ruoqi; Jiang, Haoying; Su, Hong; Cheng, Menghan; Yu, Zhe; Li, Haigang; Tang, Tao; Wang, Yang.

Afiliación

Hu E; Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.
Li Z; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.
Li T; Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.
Yang X; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.
Ding R; Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.
Jiang H; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.
Su H; Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.
Cheng M; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.
Yu Z; Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.
Li H; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.
Tang T; Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.
Wang Y; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.

Chin Med ; 18(1): 40, 2023 Apr 17.

Article en En | MEDLINE | ID: mdl-37069580

Palabras clave

3-epi-cycloastragenol; Astragaloside IV; Biotransformation; Cycloastragenol; Gut microbiota; Herbal products; Intracerebral hemorrhage; Liver; Microglia; Network pharmacology

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