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Ozone therapy for high-grade glioma: an overview.
Yanchu, Li; Rong, Pu; Rong, Cao; Li, Zhang; Xiaoyan, Yang; Feng, Wang.
Afiliación
  • Yanchu L; Head and Neck Oncology Ward, West China Hospital of Sichuan University, Chengdu, China.
  • Rong P; Oncology Department, Chengdu Fuxing Hospital, Chengdu, China.
  • Rong C; Head and Neck Oncology Ward, West China Hospital of Sichuan University, Chengdu, China.
  • Li Z; Head and Neck Oncology Ward, West China Hospital of Sichuan University, Chengdu, China.
  • Xiaoyan Y; Radiation Therapy Department, West China Hospital of Sichuan University, Chengdu, China.
  • Feng W; Head and Neck Oncology Ward, West China Hospital of Sichuan University, Chengdu, China.
Front Oncol ; 13: 1161206, 2023.
Article en En | MEDLINE | ID: mdl-37293584
ABSTRACT
High-grade gliomas (grades III and IV) are highly malignant and aggressive brain tumors that present significant treatment challenges. Despite advances in surgery, chemotherapy, and radiation therapy, the prognosis for patients with glioma remains poor, with a median overall survival (mOS) range of 9-12 months. Therefore, exploring new and effective therapeutic strategies to improve glioma prognosis is of utmost importance and ozone therapy is a viable option. Ozone therapy has been used in various cancers, such as colon, breast, and lung, yielding significant results in preclinical studies and clinical trials. Only a few studies have been conducted on gliomas. Furthermore, since the metabolism of brain cells involves aerobic glycolysis, ozone therapy may improve the oxygen condition and enhance glioma radiation treatment. However, understanding the correct ozone dosage and optimal time of administration remains challenging. Herein, we hypothesize that ozone therapy should be more effective in gliomas compared with other tumors. This study provides an overview of the use of ozone therapy in high-grade glioma, including mechanisms of action, preclinical data, and clinical evidence.
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Ozonoterapia Idioma: En Revista: Front Oncol Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Ozonoterapia Idioma: En Revista: Front Oncol Año: 2023 Tipo del documento: Article País de afiliación: China