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Toxic effects of Aroclor 1254 on rat liver and modifying roles of selenium.
Balci Özyurt, Aylin; Erkekoglu, Pinar; Zeybek, Naciye Dilara; Asci, Ali; Yaman, Ünzile; Oflaz, Ofcan; Kizilgün, Murat; Iscan, Evin; Batur, Tugçe; Öztürk, Mehmet; Koçer-Gümüsel, Belma.
Afiliación
  • Balci Özyurt A; Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
  • Erkekoglu P; Department of Toxicology, School of Pharmacy, Bahçesehir University, İstanbul, Turkey.
  • Zeybek ND; Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
  • Asci A; Department of Histology and Embryology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Yaman Ü; Department of Toxicology, Faculty of Pharmacy, Selçuk University, Konya, Turkey.
  • Oflaz O; Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
  • Kizilgün M; Department of Toxicology, Faculty of Pharmacy, İzmir Katip Çelebi University, İzmir, Turkey.
  • Iscan E; Department of Medical Biology, Faculty of Medicine, Lokman Hekim University, Ankara, Turkey.
  • Batur T; Gulhane Faculty of Medicine, University of Health Sciences, Ankara, Turkey.
  • Öztürk M; Izmir Biomedicine and Genome Center, Izmir, Turkey.
  • Koçer-Gümüsel B; Izmir International Biomedicine and Genome Institute, Dokuz Eylül University, Izmir, Turkey.
Int J Environ Health Res ; 33(12): 1289-1304, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37309736
ABSTRACT
Polychlorinated biphenyls (PCBs) were used in different industrial areas and banned due to their high toxicity. Aroclor 1254 (A1254), commercial PCB congener, accumulates in environment leading to high human exposure. A1254 may cause hepatotoxicity, metabolic and endocrine disorders. In our study, 3-week-old male rats were separated into 6 groups C (0.15 mg/kg Se in diet); SeS (1 mg/kg Se in diet); SeD (0.05 mg/kg Se in diet); A1254 receiving groups (A; ASeS; ASeD) were given 10 mg/kg/day A1254 orally for last 15 days of feeding period with control, SeD or SeS diet, respectively, for 5 weeks. Histopathology, oxidant/antioxidant balance, apoptosis and cell cycle proteins (p53, p21) in liver were evaluated. Our results suggest that A1254 leads to changes in histology, oxidative stress and apoptosis. Selenium deficiency augments oxidative stress and apoptosis while selenium supplementation is partially protective. More mechanistic in vivo experiments are necessary for evaluation of hepatotoxicity of PCBs.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Selenio / Bifenilos Policlorados / Enfermedad Hepática Inducida por Sustancias y Drogas Idioma: En Revista: Int J Environ Health Res Año: 2023 Tipo del documento: Article País de afiliación: Turquía

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Selenio / Bifenilos Policlorados / Enfermedad Hepática Inducida por Sustancias y Drogas Idioma: En Revista: Int J Environ Health Res Año: 2023 Tipo del documento: Article País de afiliación: Turquía